Singapore, October 21st, 2025 – For quite some time, skin boosters have been the go-to treatment to improve overall skin health and hydration. As aesthetic medicine continues to evolve, a new generation of skin boosters emerges to provide more than just hydration but also enhanced skin rejuvenation.
Hyaluronic Acid skin boosters, such as Profhilo, remain a popular treatment to restore hydration and firmness. Beyond that, there are also new skin booster formulations aimed at rejuvenation, including the ones with regenerative ingredients, such as Polynucleotides or a hybrid combination of HA and Poly-DL-lactic Acid (PDLLA).
Exploring Different Types of Skin Boosters
Profhilo
Profhilo is an early type of Hyaluronic Acid skin booster, widely known for its hydration properties. This injectable is based on naturally occurring molecules in our skin, as Hyaluronic Acid can bind up to around a thousand times its weight in water. The hydration Profhilo offers leaves the skin plump and radiant.
Juvelook
Juvelook is a hybrid skin booster that combines HA and PDLLA to provide two benefits at the same time. The 71.5% Hyaluronic Acid (HA) provides hydration and volume, while PDLLA stimulates collagen production, gradually improving skin texture and firmness.
Rejuran
Originally from South Korea, Rejuran is currently trending for its ability to restore elasticity and firmness to the skin. Using Polynucleotides derived from salmon DNA, it works by signalling molecules and triggers the skin to produce collagen and elastin. This mechanism further boosts the skin healing process.
Rejuran focuses on regeneration and barrier repair, but also comes with improvements in skin hydration.
What Types of Korean Polynucleotides Are Available?
For Rejuran in particular, there are three different types available, each with specific formulations and a final result for the skin:
Rejuran Eye
- Formulation: Low viscosity
- Targeted Skin Concerns: Wrinkles around the eyes or dark circles
- Expected Result: Subtle lift and improve overall skin health around the eye area
Rejuran Healer
- Formulation: Moderate viscosity
- Targeted Skin Concerns: All over the face and neck rejuvenation
- Expected Result: Strengthen the skin’s barrier and support an overall rejuvenated and even complexion
Rejuran S
- Formulation: High viscosity
- Targeted Skin Concerns: Severe acne scars and uneven skin texture
- Expected Result: Fill in hollow acne scars, improve skin elasticity, and clarity
The Different Traits Between Profhilo, Juvelook, and Rejuran
Now, let’s compare the unique differences between Profhilo, Juvelook, and Rejuran based on their mechanisms and outputs.
| Profhilo | Juvelook | Rejuran | |
| Ideal Candidates | Adults with skin laxity, dryness, or fine lines. | Adults who have large pores, severe acne, dull skin, or mild aging signs. | Adults with early aging signs or who want to improve overall skin health |
| Key Benefits |
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| Results Longevity | 6-9 months | 1-2 years | 6-12 months |
| Sessions Needed | 2-3 sessions | 2-3 sessions | 2-3 sessions |
| Side Effects | Redness, swelling, and bruising on treated areas, which will subside within a few days. | Redness, itchiness, swelling, and temporary numbness in treated areas, which will subside within a few days. | Redness, swelling, and mild bruising in treated areas, which will subside within a few days. |
Choosing The Right Skin Booster
To sum up, the “best” skin booster is not necessarily the popular one, but rather which one that can address your skin concerns effectively. Key factors, such as choosing the licensed clinic and aesthetic doctors, are also important to ensure that the treatment process goes smoothly with minimal side effects. Always have a thorough consultation with your doctors about your skin concerns and the aesthetic result that you prefer, to ensure that the results align with your expectations.